Â鶹´«Ã½¸ßÇå°æ

Evo-Devo@Bangor

My main research interest is in the way that genomic changes have influenced animal evolution and development. Current research projects focus on the GC-biased mutation in desert rodents, snake venom evolution, and the mechanisms by which the uterine environment can change gene expression in the embryo.

Location: Room E1, 4th floor Brambell Building

Telephone: +44 (0)1248 383492

Personal webpage:

Twitter: @

• DPhil: The Evolution of Vertebrate ParaHox Genes
  Oxford University, 2007
• MSc: Biosystematics
  Grand Challenges in Ecosystem and the Environment Initiative, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK alexander.papadopulos@plants.ox.ac.uk., 2003
• BSc: Genetics
  Department of Molecular and Clinical Pharmacology, University of Liverpool, 2002

Comparative genomics

I have a long-standing interest in vertebrate genome evolution, especially as it relates to gene and genome duplication, and/or the evolution of novelty. Whole genome duplications look likely to have played a significant role in the evolution of vertebrates, and particularly the development of vertebrate innovations, and gene duplication has been an important factor in the origin and diversification of snake venom.

Postgraduate opportunities in this area relate to the evolution of vertebrate homeobox genes; GC-biased mutation in desert rodents; and snake venom evolution, taking advantage of recent advances in long-read sequencing and techniques for the assembly of chromosome-scale genome assemblies such as Hi-C.

Evolution and Development (Evo-Devo)

Changes to embryonic development can have major effects on adult morphology, and the evolution of developmental processes has been a major driver of animal evolution.

Postgraduate opportunities in this area relate to my current research into vertebrate axial patterning, and particularly how the uterine environment might influence numbers and types of vertebrae in mouse models. These projects would require management of rodent breeding programs; collection of embryos; antibody-based hormones assays, and gene/protein expression studies. There is scope for expansion of this research into studies of human and non-human primate vertebral variation.  

Snake venom evolution

The availability of whole genome sequences for multiple snake species is providing unprecedented insight into the processes underlying the origin and diversification of snake venom. Â鶹´«Ã½¸ßÇå°æ is one of the few Universities in the UK that maintains a collection of venomous snakes, and this invaluable resource facilitates research into the genetic factors responsible for inter- and intra-species variation in snake venom composition.

Postgraduate opportunities in this area relate to the determination of the gene and genome level mechanisms that drive variation in venom composition within and between species.

2024

• Cyhoeddwyd
  Major, T., Jeffrey, L., Limia Russel, G., Bracegirdle, R., Gandini, A., Morgan, R., Marshall, B. M., Mulley, J. & Wüster, W., 3 Medi 2024, BioRxiv, 29 t.
  Allbwn ymchwil: Papur gweithio › Rhagargraffiad

2023

• Cyhoeddwyd
  Brekke, T. D., Papadopulos, A. S. T., Julia, E., Fornas, O., Fu, B., Yang, F., de la Fuente, R., Page, J., Baril, T., Hayward, A. & Mulley, J., Mai 2023, Yn: Molecular Biology and Evolution. 40, 5, msad115.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Rogerson, G., Bock, S., Loera, Y., Parrott, B. & Mulley, J., 31 Maw 2023, Yn: Journal of Experimental Biology. 226, 6, jeb245219.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Major, T., Bracegirdle, R., Gandini, A., Limia Russel, G., Pozzi, A., Morgan, R., Mulley, J. & Wüster, W., 17 Ion 2023, Yn: Herpetology Notes. 16, t. 51-54 4 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Brekke, T. D., Shier, L., Hegarty, M. J. & Mulley, J., Medi 2023, Yn: Conservation Genetics Resources. 15, 3, t. 117-124 8 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Falk, S. & Mulley, J., 31 Ion 2023, Yn: Wellcome Open Research . 8, 43, t. 43
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Crowley, L. M., Telfer, M., Geiser, M. & Mulley, J., 13 Ebr 2023, Wellcome Open research, t. 169, (Wellcome open research).
  Allbwn ymchwil: Papur gweithio › Rhagargraffiad
• Cyhoeddwyd
  Mulley, J., Lees, D., programme, W. S. I. T. O. L. & Consortium, D. T. O. L., 20 Rhag 2023, Yn: Wellcome Open Research . 8, 578
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Mulley, J. & Boyes, D., 9 Chwef 2023, Yn: Wellcome Open Research . 8, t. 66
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Boyes, D., Mulley, J. F. & Consortium, D. T. O. L., 23 Maw 2023, Yn: Wellcome Open Research. 8, 129, t. 129 1 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Boyes, D. & Mulley, J., 8 Chwef 2023, Yn: Wellcome Open Research . 8, 63.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Boyes, D. & Mulley, J., 31 Ion 2023, Yn: Wellcome Open Research . 8, 45
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Boyes, D., Mulley, J., collective, D. T. O. L. B. & programme, W. S. I. T. O. L., 8 Medi 2023, Yn: Wellcome Open Research . 8, 399
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Boyes, D., Mulley, J., collective, D. T. O. L. B. & programme, W. S. I. T. O. L., 12 Hyd 2023, Yn: Wellcome Open Research . 8, 441
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Crowley, L. M., Mulley, J. F., Lab, U. O. O. A. W. W. G. A., collective, D. T. O. L. B., programme, W. S. I. T. O. L., collective, W. S. I. S. O. D. P., collective, T. O. L. C. I. & Consortium, D. T. O. L., 21 Meh 2023, Yn: Wellcome Open Research. 8, 258
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Falk, S. & Mulley, J., 12 Ion 2023, Yn: Wellcome Open Research . 8, 17
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Falk, S. & Mulley, J., 8 Chwef 2023, Yn: Wellcome Open Research . 8, 65, t. 65
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Falk, S., Mulley, J. F. & Consortium, D. T. O. L., 30 Awst 2023, Yn: Wellcome Open Research. 8, 373
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Falk, S. & Mulley, J., 2 Meh 2023, Wellcome Open research, t. 234, (Wellcome open research).
  Allbwn ymchwil: Papur gweithio › Rhagargraffiad

2022

• Cyhoeddwyd
  Mulley, J., Ebr 2022, Yn: Journal of Anatomy. 240, 4, t. 735-745 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Crowley, L. M. & Mulley, J., 5 Gorff 2022, Wellcome Open Research , 7, 178, t. 178 1 t.
  Allbwn ymchwil: Cyfraniad at gyhoeddiad arbenigol › Erthygl

2020

• Cyhoeddwyd
  Payne, M., Mulley, J. & Winder, I. C., Ebr 2020.
  Allbwn ymchwil: Cyfraniad at gynhadledd › Crynodeb › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Parcana, R., Hargreaves, A. D., Mulley, J. & Holland, P. W. H., 1 Awst 2020, Yn: Molecular Biology and Evolution. 37, 8, t. 2197-2210 msaa072.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2019

• Cyhoeddwyd
  Brekke, T., Mulley, J., Steele, K., Denver, M., Thom, A. & Supriya, S., Ebr 2019, Yn: Mammalian Genome. 30, 3-4, t. 63-70 8 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Payne, M., Winder, I. C. & Mulley, J., 18 Rhag 2019.
  Allbwn ymchwil: Cyfraniad at gynhadledd › Murlen › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Mulley, J. F., Tach 2019, Yn: BioEssays : news and reviews in molecular, cellular and developmental biology. 41, 11
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Zancolli, G., Calvete, J. J., Cardwell, M. D., Greene, H. W., Hayes, W. K., Hegarty, M. J., Herrmann, H.-W., Holycross, A. T., Lannutti, D. I., Mulley, J. F., Sanz, L., Travis, Z. D., Whorley, J. R., Wuster, C. E. & Wuster, W., 13 Maw 2019, Yn: Proceedings of the Royal Society B: Biological Sciences. 286, 1898, t. 20182735
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2018

• Cyhoeddwyd
  Brekke, T., Steele, K. & Mulley, J., 1 Chwef 2018, Yn: G3: Genes, Genomes, Genetics. 8, 2, t. 679-686
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Hawkins, P., McBride, A., Paiba, G., Rose, R., Prescott, M. J., Mulley, J., Izzard, S., Ridley, D., Kappel, S., Melotti, L. & Hubrecht, R., Hyd 2018, Yn: Animal Technology and Welfare. 17, 2, t. 75-42
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2017

• Cyhoeddwyd
  Hargreaves, A. D., Zhou, L., Christensen, J., Marletaz, F., Liu, S., Li, F., Jansen, P. G., Spiga, E., Hansen, M. T., Pedersen, S. V. H., Biswas, S., Seriwaka, K., Fox, B. A., Taylor, W. R., Mulley, J., Zhang, G., Heller, R. S. & Holland, P. W. H., 18 Gorff 2017, Yn: Proceedings of the National Academy of Sciences of the United States of America: PNAS. 114, 29, t. 7677–7682
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2016

• Cyhoeddwyd
  Braasch, I., Gehrke, A. R., Smith, J. J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A. M., Campbell, M. S., Barrell, D., Martin, K. J., Mulley, J. F., Ravi, V., Lee, A. P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F. E., Sun, Y., Hertel, J., Beam, M. J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J. H., Litman, G. W., Litman, R. T., Mikami, M., Ota, T., Saha, N. R., Williams, L., Stadler, P. F., Wang, H., Taylor, J. S., Fontenot, Q., Ferrara, A., Searle, S. M., Aken, B., Yandell, M., Schneider, I., Yoder, J. A., Volff, J., Meyer, A., Amemiya, C. T., Venkatesh, B., Holland, P. W., Guiguen, Y., Bobe, J., Shubin, N. H., Di Palma, F., Alföldi, J., Lindblad-Toh, K. & Postlethwait, J. H., 7 Maw 2016, Yn: Nature Genetics.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2015

• Cyhoeddwyd
  Hargreaves, A. D., Tucker, A. S., Mulley, J. F., Gopalakrishnakone, P. (Golygydd) & Malhotra, M. (Golygydd), 8 Awst 2015, Evolution of Venomous Animals and Their Toxins: Toxicology. Springer Netherlands, t. 1-15
  Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod
• Cyhoeddwyd
  Hargreaves, A. D. & Mulley, J. F., 24 Tach 2015, Yn: PeerJ. t. e1441
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2014

• Cyhoeddwyd
  Hargreaves, A. D. & Mulley, J. F., 27 Awst 2014, Yn: Toxicon. 90, t. 351-353
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Mulley, J. F. & Holland, P. W., 1 Medi 2014, Yn: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 322, 6, t. 352-358
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Hargreaves, A. D., Swain, M. T., Hegarty, M. J., Logan, D. W. & Mulley, J. F., 30 Gorff 2014, Yn: Genome Biology and Evolution. 6, 8, t. 2088-2095
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Hargreaves, A. D., Swain, M. T., Logan, D. W. & Mulley, J. F., 17 Hyd 2014, Yn: Toxicon. 92, t. 140-156
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Mulley, J. F., Hargreaves, A. D., Hegarty, M. J., Heller, R. S. & Swain, M. T., 6 Rhag 2014, Yn: BMC Genomics. 15, 1074
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2010

• Cyhoeddwyd
  Mulley, J. F. & Holland, P. W., 12 Mai 2010, Yn: Molecular Biology and Evolution. 27, 10, t. 2386-2391
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

• Cyhoeddwyd
  Mulley, J. F., Zhong, Y. F. & Holland, P. W., 2 Medi 2009, Yn: BMC Evolutionary Biology. 9, t. 218
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2008

• Cyhoeddwyd
  Furlong, R. F. & Mulley, J. F., 25 Hyd 2008, Yn: Zoological Science. 25, 10, t. 955-9 5 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid

2006

• Cyhoeddwyd
  Mulley, J. F., Chiu, C.-H. & Holland, P. W. H., 5 Gorff 2006, Yn: Proceedings of the National Academy of Sciences of the United States of America. 103, 27, t. 10369-72 4 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2004

• Cyhoeddwyd
  Mulley, J. & Holland, P., 21 Hyd 2004, Yn: Nature. 431, 7011, t. 916-7 2 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• Cyhoeddwyd
  Daly, D., Waltham, K., Mulley, J., Watts, P., Rosin, A., Kemp, S. & Saccheri, I., Meh 2004, Yn: Molecular Ecology Notes. 4, 2, t. 179-181
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2023

• 25 Gorff 2023 – 27 Gorff 2023

  Gweithgaredd: Cymryd rhan mewn cynhadledd Academaidd (Trefnydd)

• 01/06/2019 – 30/09/2023 (Wedi gorffen)

• 01/02/2019 – 30/06/2020 (Wedi gorffen)

• 01/11/2017 – 31/12/2017 (Wedi gorffen)

• 01/11/2017 – 15/03/2018 (Wedi gorffen)

• 01/02/2017 – 30/05/2018 (Wedi gorffen)

• 01/06/2016 – 01/08/2019 (Wedi gorffen)

• 01/04/2011 – 31/08/2012 (Wedi gorffen)

• 01/02/2011 – 31/03/2013 (Wedi gorffen)

• 01/08/2010 – 31/08/2014 (Wedi gorffen)