Dr Andrew Pierce

Darlithydd (Addysgu ac Ymchwil)

a.pierce@bangor.ac.uk

Dr Pierce has an extensive research background in haemopoietic stem cell biology with a special interest in the myeloid leukaemias. Having undertaken a systematic analysis of leukaemogenic protein tyrosine kinases using systems biology approaches and advanced mass spectrometry techniques (iTRAQ, SILAC, SWATH, proteogenomics and phosphopeptide analysis) he identified common effectors driving multiple leukaemias. Targeting these disrupted pathways in primary patient material and in in vivo model systems he was able to demonstrate their potential as novel treatment strategies. Much of this work included repurposing drugs with the explicit aim of improving leukaemia patient outcomes. Repurposing drugs bypasses many of the hurdles present in drug development, such as toxicity and pharmacodynamic profiling markedly reducing the time and cost to advance new treatments to the clinic. His work has also shown that mRNA level changes do not correspond to protein level changes in response to oncogene expression and that modulation of the mRNA export complex, THOC, can in part explain this phenomenon. This work is presently being expanded into research on alternative splicing in cancer, both via mutation of proteins involved in RNA splicing and as a response to radiotherapy in the context of DNA damage. Using his expertise in proteomics and ability to lead multidisciplinary teams Dr Pierce has also driven research projects in cancer biomarker discovery. All of Dr Pierce’s research is ultimately aimed at improving patient outcomes.

Location: Brambell, Room 412

Email: a.pierce@bangor.ac.uk

Current Position: Lecturer, Medical and Health Sciences

Other external Positions: Honorary Lecturer, Division of Cancer Sciences, The University of Manchester

Teaching

Programme lead for Genomics and Precision Medicine MSc.

Module coordinator for MSE-4080, Bioinformatics and Genomic data.

Module coordinator for MSE-4081, Omics Techniques and Technologies.

Module coordinator for MSE-4083, Genomics and Cancer.

Supervision

Supervision of PhD, MSc and MRes students.

Other roles

External and internal viva voce examiner

Research Impact

Developing cancer therapies that eradicate cancer stem cells and cure the disease is hugely challenging which is exemplified in Chronic Myeloid Leukaemia, an advanced paradigm of cancer stem cell research. Dr Pierce has published a true ‘’bench to bedside’’ study (Nature, 2016. PMID: 27281222) where a proteomic screen of primary leukaemic progenitor cells led to the identification of a potential cure for chronic myeloid leukaemia which entered a phase 2 clinical trial (CRUK/17/016 TASTER). Similar approaches have led to the identification of potential treatments for Polycythemia vera (Leukemia, 2017. PMID: 28533538), Juvenile Myelomonocytic leukemia (JPR, 2020. PMID: 31657576), and Chronic Myeloid leukemia (PlosOne, 2022. PMID: 35358275). A further study (Hemasphere 2019. PMID: 31723838) reporting the potential of repurposing the drug BGB324 for the treatment of myeloproliferative neoplasms prompted the company developing the drug, in clinical trial for several solid tumours, to investigate its potential in in vivo models of myeloproliferative neoplasm (Hemasphere, 2021. PMID: 34396051). This study concluded that BGB324 warrants clinical investigation for the treatment of MPN.

Endometrial cancer is the most common gynaecological malignancy in high-income countries and the sixth most common cancer in women worldwide. Early detection is key to ensuring good clinical outcomes and a non-invasive detection tool would transform patient care.  Dr Pierce has published research (Cancers, 2021. PMID: 34359700 PMID: 33578729) which has identified potential biomarkers in urine and plasma that are undergoing validation as a patient friendly endometrial cancer detection test.

’Rydwyf yn fodlon goruchwylio cwrs PhD

2024

  • Cyhoeddwyd
    Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Ebr 2024, Yn: eBioMedicine. 102, t. 105064
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2023

  • Cyhoeddwyd
    Pearson, S., Blance, R., Yan, F., Hsieh, Y.-C., Geary, B., Amaral, F. M. R., Somervaille, T. C. P., Kirschner, K., Whetton, A. D. & Pierce, A., 30 Mai 2023, Yn: PLoS ONE. 18, 5, 16 t., 0286412.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da Sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 18 Mai 2023, Yn: British Journal of Cancer. 128, 9, t. 1723-1732 10 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Polenkowski, M., Allister, A. B., Burbano de Lara, S., Pierce, A., Geary, B., El Bounkari, O., Wiehlmann, L., Hoffmann, A., Whetton, A. D., Tamura, T. & Tran, D. D. H., 20 Ion 2023, Yn: iScience. 26, 1, 105784.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2022

  • Cyhoeddwyd
    Pearson, S., D. Whitton, A. & Pierce, A., 31 Maw 2022, Yn: PLoS ONE. 17, 3, 11 t., e0266298.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Maiques-Diaz, A., Nicosia, L., Basma, N. J., Romero-Camarero, I., Camera, F., Spencer, G. J., Amaral, F. M. R., Simeoni, F., Wingelhofer, B., Williamson, A. J. K., Pierce, A., Whetton, A. D. & Somervaille, T. C. P., 28 Hyd 2022, Yn: Oncogene. 41, 44, t. 4841-4854 14 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2021

  • Cyhoeddwyd
    Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Gorff 2021, Yn: Cancers.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Njoku, K., Campbell, A. E., Geary, B., MacKintosh, M. L., Derbyshire, A. E., Kitson, S. J., Sivalingam, V. N., Pierce, A., Whetton, A. D. & Crosbie, E. J., 10 Chwef 2021, Yn: Cancers. 13, 4, t. 718 1 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2020

  • Cyhoeddwyd
    Paredes, R., Schneider, M., Pearson, S., Teng, H. Y., Kelly, J. R., Pierce, A., Somervaille, T. C. P., Whetton, A. D. & Meyer, S., 2020, Yn: Molecular Biology Reports. 47, 10, t. 8293-8300 8 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A. & Meyer, S., 20 Hyd 2020, Yn: Cell Death and Disease. 11
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L. & Tonks, A., 2020, Yn: Leukemia. 34, 2, t. 427-440 14 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2019

  • Cyhoeddwyd
    Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Ebr 2019, Yn: HemaSphere.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Taylor, S., Littler, S., Sloss, O., Geary, B., Pierce, A. & Whetton, A., 28 Awst 2019, Yn: Open Biology.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, Yn: Journal of Proteome Research.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2018

  • Cyhoeddwyd
    Paredes, R., Schneider, M., Stevens, A., White, D. J., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J. R., Connors, K., Wiseman, D. H., Chadwick, J. A., Löffler, H., Teng, H. Y., Lovell, S., Unwin, R., van de Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T. C. P., Pierce, A., Whetton, A. D. & Meyer, S., 1 Meh 2018, Yn: Nucleic Acids Research. 46, 15, t. 7662-7674 13 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2017

  • Cyhoeddwyd
    Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M.-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, Yn: Cell Death and Disease. 8, 6, t. e2875-e2875
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    S, P., AJK, W., R, B., TCP, S., S, T., N, A., AD, W. & A, P., 1 Rhag 2017, Yn: Leukemia. 31
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2016

  • Cyhoeddwyd
    A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, Yn: Oncotarget.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    SA, A., LE, H., E, C., ME, D., K, D., AJ, W., K, K., P, B., LE, P., MT, S., F, P., Pierce, A., M, C., C, N., SM, G., D, V., AD, W. & TL, H., 2016, Yn: Nature. 534, t. 341-346
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    PA, C., EJ, C., M, A.-O., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, Yn: BMJ Open Respiratory Research.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    AD, W., NC, A., S, P., E, J., L, Z., R, B., AC, K., A, N., S, T., AJ, W. & A, P., 2016, Yn: Oncotarget.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2015

  • Cyhoeddwyd
    M, A.-O., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, Yn: Natur Protocols.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2014

  • Cyhoeddwyd
    C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Rhag 2014, Yn: Bioinformatics. t. 549-558
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    DD, T., S, S., AJ, W., Pierce, A., O, D.-B., L, W., A, K., AD, W. & T, T., 2014, Yn: Nucleic Acids Research. 42, 19
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    F, P., MT, S., GV, H., LE, H., EK, A., M, A.-O., M, C., A, P., BJ, H., AD, W. & TL, H., 18 Awst 2014, Yn: Stem Cells. 32, 9, t. 2324-2337
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2013

  • Cyhoeddwyd
    F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Hyd 2013, Yn: Leukemia. 27, t. 932-940
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    AJ, W., A, P., E, J., C, Z., M, A.-O., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Tach 2013, Yn: Molecular and Cellular Proteomics. 3319 t.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    DJ, W., RD, U., E, B., A, P., HY, T., J, M., B, G., TD, S., J, G., S, L., TC, S., R, D., AD, W. & S, M., 12 Meh 2013, Yn: PLoS ONE.
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., AD, W., S, M., F, R.-K., G, B., KR, C., N, Z. & S, K., 11 Ebr 2013, Yn: Proteomics. 13, 14, t. 2216-2224
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2012

  • Cyhoeddwyd
    F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Meh 2012, Yn: Journal of Proteomics. 77, t. 14-26
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 2012, Yn: PLoS ONE. 8, 6
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2010

  • Cyhoeddwyd
    CF, L., S, G., E, R.-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Medi 2010, Yn: Proteomics. 10, 18, t. 3321-3342
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    E, D., C, G., RW, F., RD, U., JR, G., A, P., AD, W. & H, W., Tach 2010, Yn: Stem Cell Research. 5, 3, t. 226-243
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

  • Cyhoeddwyd
    L, C., A, P., M, R., MB, G. S., HG, H., L, Z., T, T. & AD, W., Chwef 2009, Yn: Cellular Signalling. 21, 2, t. 309-316
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2008

  • Cyhoeddwyd
    Pierce, A., RD, U., CA, E., S, G., L, C., L, Z., E, J., CF, L., D, B., MJ, O., CJ, M., DA, B., E, S. & AD, W., 1 Mai 2008, Yn: Molecular and Cellular Proteomics. 7, 5, t. 853-863
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., L, C., HG, H., JR, G., L, Z., BA, W., MB, G. S., T, T., D, S. & AD, W., 15 Ebr 2008, Yn: British Journal of Haematology. 141, 5, t. 641-650
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2006

  • Cyhoeddwyd
    L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, Yn: Blood. t. 1716-1723
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., Y, L., HG, H., S, T., PJ, O.-L., AD, W. & E, S., 31 Maw 2006, Yn: British Journal of Haematology. 133, 3, t. 345-352
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    RD, U., DL, S., D, B., CL, W., CJ, M., CA, E., E, J., SA, B., K, B., A, P., E, S. & AD, W., 15 Meh 2006, Yn: Blood. 107, 12, t. 4687-4694
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    N, U.-D., Pierce, A., SE, T., D, X., AD, W. & PJ, O.-L., 13 Chwef 2006, Yn: British Journal of Haematology. 132, 6, t. 774-783
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2005

  • Cyhoeddwyd
    HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Awst 2005, Yn: Leukemia. t. 1851-1853
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    RD, U., DW, S., Y, L., A, P., DG, G. & AD, W., Chwef 2005, Yn: Journal of Biological Chemistry. 280, 8, t. 6316-6326
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., RD, U., A, P., RB, W., DW, S. & AD, W., 1 Gorff 2005, Yn: Molecular and Cellular Proteomics. 4, 7
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2004

  • Cyhoeddwyd
    D, X., Pierce, A., N, U.-D., AD, W. & PJ, O.-L., Chwef 2004, Yn: Cellular Signalling. 16, 2, t. 145-156
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 Mai 2004, Yn: Blood. t. 3751-3759
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2003

  • Cyhoeddwyd
    C, L., CA, E., E, S., A, P., R, M. & AD, W., 3 Medi 2003, Yn: British Journal of Haematology. 122, 6, t. 985-995
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    AD, W., Y, L., A, P., L, C. & E, S., 15 Hyd 2003, Yn: Blood. 102, 8, t. 2798-2802
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2002

  • Cyhoeddwyd
    Pierce, A., E, S., S, A. & AD, W., 2002, Yn: Oncogene. 21, t. 3068-3075
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Tach 2002, Yn: Molecular and Cellular Proteomics. 1, 11, t. 876-884
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    CA, E., S, A., A, P. & AD, W., 1 Tach 2002, Yn: Blood. 100, 9, t. 3164-3174
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2001

  • Cyhoeddwyd
    Pierce, A., DL, S., LV, J., AD, W. & E, S., 2001, Yn: The Hematology Journal. 2, 4, t. 257-264
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2000

  • Cyhoeddwyd
    Pierce, A., E, S., S, W., C, D., JM, F., J, M., PJ, O.-L., TM, D. & AD, W., 16 Tach 2000, Yn: Oncogene. 19, t. 5487-5497
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    AM, B., R, M., A, P., GS, L., N, R., JA, M. & AD, W., 1 Hyd 2000, Yn: Molecular Medicine. 6, t. 892-902
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    JM, F., CM, H., E, S., A, P., TM, D. & AD, W., Rhag 2000, Yn: Journal of Biological Chemistry. 275, 50, t. 39137-39145
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1999

  • Cyhoeddwyd
    CA, E., Pierce, A., SA, W., E, S., CM, H. & AD, W., 1 Medi 1999, Yn: Blood. 94, 5, t. 1504-1514
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    H, C., Pierce, A. & T, W., Rhag 1999, Yn: Chinese Journal of Cancer Research. 11, t. 245-248
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1998

  • Cyhoeddwyd
    Pierce, A., CM, H., SE, N., E, S., TM, D., JM, L., PJ, O.-L., G, W. & AD, W., 23 Maw 1998, Yn: Journal of Cell Biology. 140, 6, t. 1511-1518
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., AD, W., PJ, O.-L., J, T., E, S., TM, D. & CM, H., 15 Maw 1998, Yn: Journal of Cell Science. t. 815-823
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
  • Cyhoeddwyd
    Pierce, A., PJ, O.-L., E, S., TM, D. & AD, W., 10 Awst 1998, Yn: Oncogene. 17, t. 667-672
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1997

  • Cyhoeddwyd
    Pierce, A. & AD, W., 1 Mai 1997, Yn: Biochemical Society Transactions. 25, 2, t. 366-370
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1996

  • Cyhoeddwyd
    Evans, C. A. & Pierce, A., 1996, Blood Cell Biochemistry: Hematopoietic Cell Growth Factors and Their Receptors. Whetton, A. D. & Gordon, J. (gol.). Boston, MA: Springer US, t. 99-120 22 t.
    Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid

1995

  • Cyhoeddwyd
    RC, C., GS, L., PJ, O.-L., A, P. & AD, W., 1 Rhag 1995, Yn: Blood. 86, 11, t. 4270-4277
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1992

  • Cyhoeddwyd
    Pierce, A., M, L., IN, H., GJ, C. & JT, G., 25 Chwef 1992, Yn: Journal of Biological Chemistry. 267, 6, t. 3894-3900
    Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

  • 01/10/2022 – 31/03/2024 (Wedi gorffen)

GRANTS AWARDED

2020-2023ÌýÌýÌý Fanconi Hope (92K). Investigations into Proton Beam Therapy in Fanconi Anaemia (CoI).

2019-2022ÌýÌýÌý Bloodwise (£300K). Eradication of the leukaemic clone in myeloproliferative neoplasms (PI).

2019-2021ÌýÌýÌý FRGS, MASTIC (35K). The antileukemic activity and mechanisms of action of Lignosus rhinocerotis (CoI).

2013-2018    Leukaemia Lymphoma Research (£1.8M). Application of advanced protein technologies to identify common treatment targets for myeloid leukaemias (CoI).

2016-2016    ISSF Strategic Awards in Precision Medicine (£15K). Developing a plasma-based biomarker for the early identification and stratification of Alzheimer’s disease (CoI).

2016-2016    BloodWise summer studentship (1.5K). CD45 in myeloproliferative neoplasms (PI).

2015-2017ÌýÌýÌý Manchester Royal Infirmary MD studentship (£268K). Assessment of abnormal signal pathway activation in acute myeloid leukaemia characterised by FLT3/ITD: application to treatment design and monitoring (CoI).

Contributions to the Scientific community

Dr Pierce regularly reviews grant applications for international funding bodies and manuscripts for a wide range of internationally renowned journals such as EMBO, Blood, Molecular Cellular Proteomics and Oncogene. He has also served as external Ph.D. examiner. Dr Pierce has collaborated widely both nationally and internationally having published research manuscripts with groups from amongst others Manchester, Liverpool, Glasgow, Cardiff, Hanover, Frieberg, Houston and New York.

Work Biography

Previous Positions

2005 – 2022            Research Fellow, Stem Cell and Leukaemia Proteomics Laboratories University of Manchester

1998 - 2005             Research Fellow, Cellular Development Unit, UMIST

1992 - 1998             Research Associate, Cellular Development Unit, UMIST

Education

1989 - 1992            PhD: The cloning and sequencing of plasma membrane Heparan Sulphate Proteoglycans. Paterson Institute for Cancer Research, Manchester.