Additional Contact Information
Martina Lahmann is working at the Organic Chemistry/Life Science interface (Chemical Biology). Her expertise is in organic synthesis, carbohydrate and glycoconjugate chemistry.
Martina received her diploma in Chemistry at the University of Hamburg, Germany, in 1994. She continued her work in the group of Prof. Joachim Thiem and obtained her Ph.D. in Organic Chemistry in 1997. Thereafter she moved to Stockholm University, Sweden, to work as a postdoc with Prof. Per J. Garegg and Prof. Stefan Oscarson. In 2002 she moved to G枚teborg University, Sweden, to supervise the part of Stefan鈥檚 group which was relocated to G枚teborg University, to lecture Organic Chemistry, and then to develop her independent research. In September 2005 she received the Docent degree in Organic Chemistry from G枚teborg University. After a year in the Arrhenius Laboratory at Stockholm University, focussing on her research, Martina joined us at Bangor in September 2007.
The major focus on her current research comprises the development of new tools and structures for the identification and analysis of carbohydrate recognition domains, directing to a deeper understanding of carbohydrate-protein interactions on the molecular level, which eventually allows a more rational design and development of carbohydrate-based pharmaceuticals. Adhesion of bacteria to human glycoconjugate receptors is a crucial step in the development of many diseases and is often mediated by carbohydrate-protein interactions. As model system, she focuses on the binding of Helicobacter pylori (collaborators S. Oscarson, University College Dublin, and T. Bor茅n, University of Ume氓) which induces chronic inflammation by attaching itself to carbohydrate structures in the stomach lining. Another bacterial target is the uropathogenic Escherichia coli (UPEC), accounting for more than 80 % of urinary tract infections. To inhibit the adhesion of bacteria to the bladder is proposed to be an alternative approach to challenge antibiotic resistance. Transferred to the lab-bench this spans from 鈥減lain鈥 oligosaccharide synthesis (e.g. Lewis-blood group structures), variously tagged carbohydrate structures (e.g. photolabeling, selenoglycosides) to designed conjugates (e.g. glycocluster, dendrimers).
The exploration of glycosylation reactions, e.g. solvent dependency, and the development of protecting group- and conjugation techniques represents another research-area.
Research Interests
Research
Welcome to the Carbohydrate Lab!
In our laboratory almost everything orbits carbohydrates. Carbohydrates represent - also outside the lab - the most abundant family of nature products.
Everybody has probably heard about
- their role as energy storage, e.g. as sucrose A - in everyday language just called 鈥榮ugar鈥,
- their capability supporting tissue in plants, e.g., cellulose B helps building up even the largest trees,
- their ability in keeping many arthropods (as insects, spiders and crustaceans) protected in their sometimes pretty hard 鈥榮kin鈥, e.g., the lobster鈥檚 shell consist mainly of a polysaccharide called chitin C.
However, complex oligosaccharide structures are essential to get biological systems working and carbohydrate structures placed e.g. on the outside of a cell-wall can behave both as flypaper and as signpost for other bio molecules. Two examples:
- the 鈥淎BO-blood-groups鈥 are assigned by carbohydrate structures present on the surface of (red blood) cells
- too old red blood cells are sorted out by the liver if they present too little sialic acids (certain carbohydrates) on their surface (because the red blood cells loose them when getting older)
As more as we understand the relevance of carbohydrates and their conjugates, the interest in possible pharmaceutical applications is growing (e.g. development of vaccines). However, compared to peptides the construction of oligosaccharides is not as automated and still often governed by 鈥榯rial and error鈥.
At this point our research begins:
Our general aim is it to understand the chemistry of carbohydrates as much as possible by studying glycosylation reactions and the development of protecting group-techniques. By doing this, we produce many biologically interesting compounds which are further examined by biochemists and biologists. Since 鈥榥aked鈥 oligosaccharides are usually too small to produce a response in a biological system, we have to 鈥榠nflate鈥 them by connecting them to carrier, e.g. proteins. In other cases it is useful to bunch several copies of the carbohydrate structures together by preparing glycoclusters or glycodendrimers. Thus, conjugation of carbohydrate structures via various spacer molecules to a carrier is another area of our research.
Some introductionary reading:
Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions.
Martina Lahmann
Top. Curr. Chem. 288 (2009), 17-65.
In: "Glycoscience and Microbial Adhesion", Th. K. Lindhorst, St. Oscarson (Eds.), Springer, Berlin/Heidelberg 2009.
Postgraduate Project Opportunities
Publications
2021
- Published
Bouillon, M., Williams, R. M., Lahmann, M. & McCabe, O., Jan 2021, Carbohydrate chemistry: Proven synthetic methods. Kosma, P., Wrodnigg, T. M. & Stutz, A. (eds.). Boca Raton: CRC Press, Vol. 5. p. 55-63
Research output: Chapter in Book/Report/Conference proceeding 鈥 Chapter 鈥 peer-review - Published
Vacchini, M., Cipolla, L., Guizzardi, R., La Ferla, B. & Lahmann, M., Jan 2021, Carbohydrate Chemistry: Proven synthetic methods. Kosma, P., Wrodnigg, T. M. & Stutz, A. (eds.). Boca Raton: CRC Press, Vol. 5. p. 189-197
Research output: Chapter in Book/Report/Conference proceeding 鈥 Chapter 鈥 peer-review
2020
- Published
Anderson, O., Beckett, J., Briggs, C. C., Natrass, L. A., Cranston, C. F., Wilkinson, E. J., Owen, J., Williams, R. M., Loukaidis, A., Bouillon, M., Pritchard, D., Lahmann, M., Baird, M. & Denny, P. W., 1 Jul 2020, In: Medicinal Chemistry. 11, 7, p. 833-842
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Bouillon, M., Bertocco, K., Bischoff, L., Buri, M., Davies, L. R., Wilkinson, E. J. & Lahmann, M., 31 Dec 2020, In: European Journal of Organic Chemistry. 2020, 48, p. 7470-7473
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Long, M., Ni Cheallaigh, A., Reihill, M., Oscarson, S. & Lahmann, M., 21 Jun 2020, In: Organic and Biomolecular Chemistry. 18, 23, p. 4452-4458
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2019
- Published
Bonnardel, F., Kumar, A., Wimmerova, M., Lahmann, M., Perez, S., Varrot, A., Lisacek, F. & Imberty, A., 7 May 2019, In: Structure. 27, 5, p. 764-775
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2018
- Published
Al-Dulayymi, J., Bouillon, M., Braganca, R., Preskett, D. & Lahmann, M., 10 Oct 2018, Patent No. WO/2016/193309
Research output: Patent
2017
- Published
Ramos-Morales, E., De La Fuente, G., Duval, S., Wehrli, C., Bouillon, M., Lahmann, M., Preskett, D., Braganca, R. & Newbold, J., 16 Mar 2017, In: Frontiers in Microbiology. 8, 399.
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Ramos-Morales, E., de la Fuente, G., Nash, R. J., Braganca, R., Duval, S., Bouillon, M., Lahmann, M. & Newbold, J., 8 Sept 2017, In: PLoS ONE. 12, 9, e0184517.
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Vetro, M., Safari, D., Fallarini, S., Salsabila, K., Lahmann, M., Penades, S., Lay, L., Marradi, M. & Compostella, F., Jan 2017, In: Nanomedicine. 12, 1
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2016
- Published
Mohammad, R., Nur-e-Alam, M., Lahmann, M., Parveen, I., Tizzard, G. J., Coles, S. J., Fowler, M., Drake, A. F., Heyes, D. & Thoss, V., Aug 2016, In: Phytochemistry. 128, p. 82-94
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Moonens, K., Gideonsson, P., Subedi, S., Bugaytsova, J., Roma玫, E., Mendez, M., Nord茅n, J., Fallah, M., Rakhimova, L., Shevtsova, A., Lahmann, M., Castaldo, G., Br盲nnstr枚m, K., Coppens, F., Lo, A. W., Ny, T., Solnick, J. V., Vandenbussche, G., Oscarson, S., Hammarstr枚m, L., Arnqvist, A., Berg, D. E., Muyldermans, S., Bor茅n, T. & Remaut, H., 13 Jan 2016, In: Cell Host and Microbe. 19, 1, p. 55-66
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2015
- Published
Lahmann, M., 2015, Manchester University Press. 16 p.
Research output: Book/Report 鈥 Commissioned report - Published
Mobarak, H., Engstrom, O., Lahmann, M., Widmalm, G., Roy, R. (ed.) & Vidal, S. (ed.), 27 May 2015, Carbohydrate Chemistry: Proven Synthetic Methods: Volume 3. 2015 ed. CRC Press, p. 81-88
Research output: Chapter in Book/Report/Conference proceeding 鈥 Chapter
2013
- Published
Houser, J., Komarek, J., Kostlanova, N., Cioci, G., Varrot, A., Kerr, S. C., Lahmann, M., Balloy, V., Fahy, J. F., Chignard, M., Imberty, A. & Wimmerova, M., 10 Dec 2013, In: PLoS ONE.
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Shan, Y., Oulaidi Lamiable, F. & Lahmann, M., 24 Jul 2013, In: Tetrahedron Letters. 54, 30, p. 3960-3961
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K-E., Lahmann, M., Lindhorst, T. K., Marradi, M., Messner, P., Molinaro, A., Murphy, P. V., Nativi, C., Oscarson, S., Penades, S., Peri, F., Pieters, R. J., Renaudet, O., Reymond, J-L., Richichi, B., Rojo, J., Sansone, F., Schaeffer, C., Turnbull, W. B., Velasco-Torrijos, T., Vidal, S., Vincent, S., Wennekes, T., Zuilhof, H. & Imberty, A., 2013, In: Chemical Society Reviews. 42, 11, p. 4709-4727
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2012
- Published
Safari, D., Marradi, M., Chiodo, F., Dekker, H. A., Shan, Y., Adamo, R., Oscarson, S., Rijkers, G. T., Lahmann, M., Kamerling, J. P., Penad茅s, S. & Snippe, H., 1 May 2012, In: Nanomedicine. 7, 5, p. 651-662
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Wellens, A., Lahmann, M., Touaibiall, M., Vaucher, J., Oscarson, S., Roy, R., Ramaut, H. & Bouckaert, J., 2012, In: Biochemistry. 51, 24, p. 4790-4799
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2011
- Published
Lahmann, M. & Thiem, J., 4 Mar 2011, In: Tetrahedron. 67, 9, p. 1654-1664
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2010
- Published
艩ul谩k, O., Delia, M., Lahmann, M., Varrot, A., Imberty, A. & Wimmerov谩, M., 13 Jan 2010, In: Structure. 18, 1, p. 59-72
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Andre, S., Lahmann, M., Gabius, H. J. & Oscarson, S., 6 Dec 2010, In: Molecular Pharmaceutics. 7, 6, p. 2270-2279
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Sundgren, A., Lahmann, M. & Oscarson, S., 26 Jul 2010, In: Beilstein Journal of Organic Chemistry. 6, p. 704-708
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Fourniere, V., Skantz, L., Sajtos, F., Oscarson, S. & Lahmann, M., 22 Jul 2010, In: Tetrahedron.
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2009
- Published
Lahmann, M., 1 Jan 2009, In: Topics in Current Chemistry. 288, p. 17-65
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Andersson, C. H., Lahmann, M., Oscarson, S. & Grennberg, H., 1 Jan 2009, In: Soft Matter. 5, 14, p. 2713-2716
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2008
- Published
Sandstrom, C., Hakkarainen, B., Matei, E., Glinchert, A., Lahmann, M., Oscarson, S., Kenne, L. & Gronenborn, A. M., 25 Mar 2008, In: Biochemistry. 47, 12, p. 3625-3635
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Safari, D., Dekker, H. A. T., Joosten, J. A. F., Michalik, D., de Souza, A. C., Adamo, R., Lahmann, M., Sundgren, A., Oscarson, S., Kamerling, J. P. & Snippe, H., Oct 2008, In: Infection and Immunity. 76, 10, p. 4615-4623
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Olsson, J. D., Eriksson, L., Lahmann, M. & Oscarson, S., 19 Sept 2008, In: Journal of Organic Chemistry. 73, 18, p. 7181-7188
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2007
- Published
Hakkarainen, B., Kenne, L., Lahmann, M., Oscarson, S. & Sandstrom, C., 1 Dec 2007, In: Magnetic Resonance in Chemistry. 45, 12, p. 1076-1080
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Arewang, C. J., Lahmann, M., Oscarson, S. & Tiden, A. K., 21 May 2007, In: Carbohydrate Research. 342, 7, p. 970-974
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2006
- Published
Gemma, E., Lahmann, M. & Oscarson, S., 24 Jul 2006, In: Carbohydrate Research. 341, 10, p. 1533-1542
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Turek, D., Sundgren, A., Lahmann, M. & Oscarson, S., 1 Jan 2006, In: Organic and Biomolecular Chemistry. 4, 7, p. 1236-1241
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Cioci, G., Mitchell, E. P., Chazalet, V., Debray, H., Oscarson, S., Lahmann, M., Gautier, C., Breton, C., Perez, S. & Imberty, A., 14 Apr 2006, In: Journal of Molecular Biology. 357, 5, p. 1575-1591
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2005
- Published
Sundgren, A., Lahmann, M. & Oscarson, S., 1 May 2005, In: Journal of Carbohydrate Chemistry. 24, 4-6, p. 379-391
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Boysen, M., Gemma, E., Lahmann, M. & Oscarson, S., 1 Jan 2005, In: Chemical Communications. 24, p. 3044-3046
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Buts, L., Wellens, A., Van Molle, I., Wyns, L., Loris, R., Lahmann, M., Oscarson, S., de Greve, H. & Bouckaert, J., 1 Aug 2005, In: Acta Crystallographica Section D: Biological Crystallography. 61, 8, p. 1149-1159
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Gemma, E., Lahmann, M. & Oscarson, S., 21 Nov 2005, In: Carbohydrate Research. 340, 16, p. 2558-2562
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Kostlanova, N., Mitchell, E. P., Lortat-Jacob, H., Oscarson, S., Lahmann, M., Gilboa-Garber, N., Chambat, G., Wimmerova, M. & Imberty, A., 29 Jul 2005, In: Journal of Biological Chemistry. 280, 30, p. 27839-27849
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2004
- Published
Aspholm-Hurtig, M., Dailide, G., Lahmann, M., Kalia, A., Ilver, D., Roche, N., Vikstrom, S., Sjostrom, R., Linden, S., Backstrom, A., Lundberg, C., Arnqvist, A., Mahdavi, J., Nilsson, U. J., Velapatino, B., Gilman, R. H., Gerhard, M., Alarcon, T., Lopez-Brea, M., Nakazawa, T., Fox, J. G., Correa, P., Dominguez-Bello, M. G., Perez-Perez, G. I., Blaser, M. J., Normark, S., Carlstedt, I., Oscarson, S., Teneberg, S., Berg, D. E. & Boren, T., 1 Jul 2004, In: Science. 305, 5683, p. 519-522
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Westerlind, U., Westman, J., Tornquist, E., Smith, C. I., Oscarson, S., Lahmann, M. & Norberg, T., 1 Jan 2004, In: Glycoconjugate Journal. 21, 5, p. 227-241
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Lahmann, M., Bulow, L., Teodorovic, P., Gyback, H. & Oscarson, S., 1 Sept 2004, In: Glycoconjugate Journal. 21, 5, p. 251-256
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Lahmann, M., Bergstrom, M. A., Turek, D. & Oscarson, S., 1 Dec 2004, In: Journal of Carbohydrate Chemistry. 23, 2, p. 123-132
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2003
- Published
Oscarsson, K., Lahmann, M., Lindberg, J., Kangasmetsa, J., Unge, T., Oscarson, S., Hallberg, A. & Samuelsson, B., 20 Mar 2003, In: Bioorganic and Medicinal Chemistry. 11, 6, p. 1107-1115
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Dahlen, A., Sundgren, A., Lahmann, M., Oscarson, S. & Hilmersson, G., 30 Oct 2003, In: Organic Letters. 5, 22, p. 4085-4088
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Buts, L., Loris, R., De Genst, E., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., De Greve, H. & Bouckaert, J., 1 Jun 2003, In: Acta Crystallographica Section D: Biological Crystallography. 59, 6, p. 1012-1015
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Suhr, R., Lahmann, M., Oscarson, S. & Thiem, J., 17 Oct 2003, In: European Journal of Organic Chemistry. 20, p. 4003-4011
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Buts, L., Bouckaert, J., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L. & De Greve, H., 1 Aug 2003, In: Molecular Microbiology. 49, 3, p. 705-715
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2002
- Published
Lahmann, M., Gyback, H., Garegg, P. J., Oscarson, S., Suhr, R. & Thiem, J., 19 Nov 2002, In: Carbohydrate Research. 337, 21-23, p. 2153-2159
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Lahmann, M. & Oscarson, S., 1 Aug 2002, In: Canadian Journal of Chemistry. 80, 8, p. 889-893
Research output: Contribution to journal 鈥 Article 鈥 peer-review - Published
Lahmann, M., Garegg, P. J., Konradsson, P. & Oscarson, S., 1 Aug 2002, In: Canadian Journal of Chemistry. 80, 8, p. 1105-1111
Research output: Contribution to journal 鈥 Article 鈥 peer-review
2000
- Published
Lahmann, M. & Oscarson, S., 30 Nov 2000, In: Organic Letters. 2, 24, p. 3881-3882
Research output: Contribution to journal 鈥 Article 鈥 peer-review
1997
- Published
Lahmann, M. & Thiem, J., 26 Mar 1997, In: Carbohydrate Research. 299, 1-2, p. 23-31
Research output: Contribution to journal 鈥 Article 鈥 peer-review
Activities
2015
2015 鈫
Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Member)
Projects
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01/06/2016 鈥 23/02/2017 (Finished)
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01/06/2015 鈥 24/02/2017 (Finished)
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01/04/2015 鈥 01/08/2019 (Finished)
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03/02/2014 鈥 08/09/2016 (Finished)
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01/10/2012 鈥 31/08/2016 (Finished)
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01/01/2001 鈥 14/12/2009 (Finished)